scott@vtx-cpd.com
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Replying to Gergana G. 20/07/2022 - 21:35
Hello.
Regarding reticulocytes, this is a brilliant recourse:
Hope that helps.
Scott 🙂
Replying to Gergana G. 20/07/2022 - 21:37
Hello.
Lovely to hear from you. Thank you for the reply.
We did do FIP serology in this case. The serology was a moderately high positive. I suppose the big issue with this is how to interpret this. Many cats will be serology positive but not have FIP.
The other investigations/imaging were more consistent with FeLV/possible lymphoma so we did not take the FIP diagnostics any further.
Scott 🙂
Regarding the bilirubin!
So, I think there is evidence of haemolysis in this case. There is a positive Coomb’s, agglutination and some ghost cells. I think this will be the reason the bilirubin is high.
The other reason that bilirubin would be high, apart from liver disease, would be hyperbilirubinemia of sepsis.
Hope that helps.
Scott 🙂
Replying to Nathalie Cunha 19/07/2022 - 18:28
Hello.
Regarding the FeLV, I would definitely follow up with an alternative test. This would normally be IFA as you mention or PCR. We carried out PCR in this case and it was confirmed as positive for FeLV. I would agree, many of the abnormalities here from a haematology POV would be explained by the FeLV.
We would normally consider blood loss and haemolysis as the main DDX for regenerative anemia. However there are cases of IMHA that are non regenerative. Up to 30% of dogs with IMHA will be non regenerative. Many more anaemia cases in cate are generally non regenerative due to some degree of BM involvement. So I would still keep haemolysis/immune mediated destruction on the list.
With the concern about possible neoplasia with FeLV we carried out abdominal US and thoracic radiography. There was evidence of abdominal lymphadenopathy.
What would your next steps be?
Scott 🙂
This is from another human review:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347500/
”However, complications of excessive gastric acid suppression, like dyspepsia, luminal dysbiosis, gastric microfloral imbalance, vitamin B12 deficiency, pernicious anemia, osteoarthritis, malabsorption of certain drugs active in the acidic microenvironment and even gastric parietal cell hyperplasia and gastric cancer staunchly warrant against rampant use of PPIs and histamine receptor blockers [104]. In fact, a recent study also indicated that PPIs can actually exacerbate indomethacin-induced small intestinal damage by detrimentally altering intestinal microbiome composition [135]. Hence, gastric acid is in no way a physiological evil and opting for anti-oxidant-based therapeutic strategy to prevent the gastric mucosa from NSAID-induced cytopathies is a rather safer approach than indiscriminate usage of acid suppressors.”
I just love the use of the words ”staunchly” and ”physiological evil”!!!
Scott 🙂
Replying to Nathalie Cunha 17/07/2022 - 18:58
Spot on!
I honestly think a good starting point for many feline anemia cases is assessing for FeLV/FIV and the haemotrophic mycoplasmas.
By definition this is either a non-regenerative anaemia or a pre-regenerative anaemia. Many feline anemia cases are mon-regenerative but it would never be a bad idea to look for free fluid in the pericardial, pleural and peritoneal spaces.
The PCV for mycoplasma was negative.
A SNAP test for FeLV was positive!Does this explain the haematology? What would you do next?
Would you trust the SNAP test as definitely positive?
Scott 🙂
Replying to Nathalie Cunha 17/07/2022 - 18:41
So, based on this reticulocyte count, this is a non regenerative anaemia.
Scott 🙂
Replying to Nathalie Cunha 17/07/2022 - 18:41
Hello Nathalie.
Lovely to hear from you! Never a stupid question!
I am really sorry if I have not been clear. The machine count is totally fine to use as long as it is an absolute number. The absolute count is expressed as a value with x10/9L, which it is in this haematology.
You have to be careful when the reticulocyte count is expressed as a percentage. That is when you have to use the calculation I mentioned.
I am sorry if I confused you!
Scott 🙂
Replying to Sarah Handley 18/07/2022 - 14:05
Should be there now!
Let me know if you have any questions.
Scott 🙂
Hello everyone.
Thank you to everyone that joined for the live session last night. Here is a link to the images that we discussed and some of the answers too:
https://drive.google.com/file/d/1HTK68JRj_wENRLpAOtx5zgnvoSKsupS5/view?usp=sharing
Let m know if you have any questions.
Scott 🙂
Replying to Sarah Handley 05/07/2022 - 15:14
Hey Sarah.
I have started a new tread to answer this brilliant question!
Scott 🙂
Replying to Frank Galea 15/07/2022 - 08:25
Hello Frank.
Lovely to hear from you and thank you you for joining our course. I was in Malta a few years back when the ECVIM congress was there. I have very fond memories.
Let me know if you have any questions.
Scott 🙂
Replying to Samad k. 15/07/2022 - 08:01
Hello Samad.
Really great to hear from you. Thank you so much for joining the course.
I hope you are enjoying the content so far. Let me know if you have any questions at any time.
Scott 🙂
Hello Jen.
I hope you are safe and well and enjoying the course. I normally sue the following dose guidelines in cats:
Xylazine (0.6 mg/kg i.m. or 1 mg/kg s.c.), dexmedetomidine (3–5 μg/kg i.m.) or medetomidine (5–20 μg/kg i.m.).
To be honest, the sedation effects of medetomidine are really unpredictable. I do normally start at the very low end of the dose and work up a little with top ups if needed.
Hope that helps.
Scott 🙂
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