scott@vtx-cpd.com
Forum Replies Created
-
AuthorPosts
-
Hello!
Hope you are well. Interesting case. Those bile acids are pretty impressive. I think repeating the sample if you have any doubt is never a bad idea. I am not sure how much more ammonia would add to this case, I am not sure I would bother running that. Aquired shunts definitely have to be a consideration but you could not completely rule out a congenital shunt! I have diagnosed them in 11-year-old dogs before!
Typical cutoff values for pre- and postprandial bile acids are 15 mcmol/L and 25 mcmol/L, respectively. Pre- and postprandial bile acids elevations have been reported to be 99% sensitive and 95-100% specific for the diagnosis of a PSS in dogs and cats. A study investigating the sensitivity and specificity of fasting bile acids in diagnosing PSS found them to be 93% and 67% in dogs, and 100% and 71% in cats, respectively. When increasing the cutoff value to 58 mcmol/L in dogs and 34 mcmol/L in cats the sensitivity was unchanged in dogs (91%) and was decreased in cats (83%), but the specificity increased in both species (84% in dogs, 86% in cats).
Falsely elevated postprandial values can occur with lipemia. When used as a test of hepatobiliary function, the magnitude of elevation in serum bile acids does not allow differentiation of the category of disease, with the exception that patients with vacuolar hepatopathy rarely have marked elevations (greater than 75-100 mcmol/L).
If increased next steps would definitely be abdominal imaging (ultrasound or CT).
Hope that helps.
Scott 🙂
Hahah!
Yes, you are right. A PEG tube and a MILA chest drain.
Scott 🙂
Yes! Indeed!
There is another tube…
Scott 🙂
Yes,
I think trimethoprim is the most reasonable choice.
Scott 🙂
Yes,
I think trimethoprim is the most reasonable choice.
Scott 🙂
Hey.
Yes, I used a combination of marbofloxacin and clindamycin. I would then change depending on culture, but many cases will come back with a surprising negative culture. Treatment with an antimicrobial drug with activity against anaerobes should be continued regardless of culture results because fastidious anaerobic bacteria could be present.
I must admit that I do not use continuous suction in these cases. I would place chest drains and use intermittent suction. We tend to use continuous suction for some pneumothorax cases:
These one-way valves can help with pneumothorax too:
Hope that helps.
Scott 🙂
I really just went for the headline with this one! I really needed to read a bit more… which I have:
Chia seeds are high in fibre and omega 3 fatty acids, phenolic acid derivatives, and flavonoids. There is some evidence to suggest they may act to bind intestinal calcium and decrease resorption of calcium from bone. This paper was designed as a retrospective case series investigating the use of chia seeds to reduce serum calcium levels in three cats with uncontrolled hypercalcemia.
Over a two-year period, three spayed female domestic shorthaired cats were diagnosed with idiopathic hypercalcemia. All cats had elevated total calcium and ionized calcium, normal PTH, calcitriol and calcidiol, low to undetectable PTHrP, and unremarkable thoracic radiographs and abdominal ultrasound. All cats were uncontrolled after 6 weeks of diet change, however had not been trialed on steroids or bisphosphonates.
Owners were directed to soak 2g/cat/day of chia seeds in water to allow mucilage formation, after which this was mixed into the cat’s diet. Supplementation was continued for 4 weeks prior to recheck of ionized calcium. At the 4 week recheck, serum calcium levels had normalized in all three cats, and remained normal 6 weeks after this.
The presence or absence of adverse effects and ease of administration were not described in this study.
There are several limitations to this study. It is a very early descriptive study with a small sample size that is unblinded, uncontrolled, and retrospective. All cats enrolled had vey mildly elevated ionized calcium levels, and all cats were trialled on different diets. None of the diets were among the highest fibre on the market.
At this point, this study in and of itself does not suffice to demonstrate that chia seeds are superior or equivalent to standard practices in controlling hypercalcemia in cats.
Really interesting though!
Scott 🙂
It really is!
Thank you. The fact that we are doing our LUTD course together is mind-blowing too!
I feel like I am the Michelle to her Beyonce… but I am OK with that!
Scott 🙂
This is really interesting.
Thank you for sharing Liz!
Scott x
Great question.
I am not sure there is one paper that totally answers this question. Several trials involving people with acute pancreatitis have demonstrated the attributes of enteral, rather than parenteral, nutrition, including decreased mortality rates. So we know we definitely have to feed them and not withhold food. In one study enteral feeding a low-fat diet via oesophagostomy tube in dogs with severe acute pancreatitis, within the first 12-24 hours of admission, was well tolerated and resulted in fewer complications when compared with parenteral nutrition. In another study, dogs with pancreatitis were fed very low fat diets (e.g., less than 25 g fat per 1000 kcal), although no significant difference in the degree of pancreatic physiologic response in healthy dogs fed diets with 16% or 5% crude fat (as fed) was reported.
Dietary management for cats with acute pancreatitis has not been well described. Excessively high fat foods should probably be avoided. Early placement of a nasogastric or esophagostomy tube is important in anorectic cats due to their risk of hepatic lipidosis. In a study of 55 cats with suspected acute pancreatitis, nasogastric tube feeding was well tolerated.
Overall, in the acute pancreatitis case, I would not get too tied up in the actual fat percentage. Choosing a food with a lower fat content is probably a good idea, but any nutrition is better than none. I do not think we have to reach for anything ultra low fat.
In chronic cases…
It is recommended that obese or hypertriglyceridemic pancreatitis dogs or cats be fed ultra-low fat diets, with fat percentage on a dry matter basis (DMB) ≤10% for dogs and ≤15% for cats. Non-obese dogs and cats without elevated triglycerides may be fed diets with <15% and <25% fat DMB, respectively. While there are commercial dog foods available which meet these criteria, there are fewer cat foods. Some low calorie or senior diets, which may not contain sufficient calories for an ill cat, are low in fat. Adverse effects have been reported with tube feeding elemental diets to cats, so a better approach may be to use a liquid diet formulated for use in cats if using a nasogastric tube. If esophageal tube feeding is used or the cat has returned to voluntary eating, a diet with moderate fat content may be used (e.g., most commercial adult maintenance diets).
Hope that helps.
Scott 🙂
p.s. The image above is the blood smear! There were a large number of these cells with very few neutrophils seen. You can see that there are no values from the hematology analyzer. They attempted to run the haematology a number of times but would not work…
Thanks so much for sharing the images.
This is an interesting case.
How has the patient done?
Scott 🙂
Message from Emma, she is struggling to post:
Hi Scott,
Thank you and thanks to your imager friend, that’s good to know regarding treatment. I did consider gastric ulceration, however only one of the hyperechoic lesions had distal acoustic shadowing. I discussed the images with an imager specialist and they were suspicious of emphasematous gastritis, with focal haemorrhage or fibrosis less likely. There is an enlarged gastric lymphnode present as well, so lymphoma couldn’t be ruled out, however with the resolution of clinical signs on treatment for gastritis only I think this is less likely.
Images:
And a video here:
https://drive.google.com/file/d/1PlHi3KvDiEsk86zXZ0jUYrmHnwx0e0Qg/view?usp=sharing
https://drive.google.com/file/d/1JHf6s7_384HxDUyHj2FGhPcZ8xJ2en6T/view?usp=sharingFrom my imaging specialist pal…
“If it is emphysematous gastritis then they would see gas in the gastric wall on ultrasound, which would appear as hyperechoic foci with reverberation artefacts, this can be difficult to appreciate when there is gas in the lumen, so usually takes several goes at looking through the gastric wall carefully and possibly from different sides/angles (pic below from that paper). Usually, the gastric wall looks thickened and abnormal as well. They may also see it on radiographs (see pic below again from paper).
It appears from that paper if the patient does not have systemic signs then they tend to do ok and the diagnosis would be more of a benign gastric emphysema and treatment wise just standard gastritis treatment. If patient not doing well, then more towards emphysematous gastritis and then they do not do very well (all patients in that paper were PTS). I specifically remember one of the cases from that paper as I scanned it, which was a case that did well and the gastric emphysema was presumed clinically insignificant in that case…. I have not had any further cases since.
If the dog in question is doing well not sure how useful any more imaging/follow-up ultrasound images of stomach would be tbh.”
Turns out she was involved with some of the cases in the paper!
Hope that helps!
Scott 🙂
Hey.
Any sedation/GA has the possibility of effecting the PCV. Mainly due to the pooling of blood in the spleen. It is totally reasonable though that we have to take blood sometimes in sedated patients I just think it is important to keep in mind the possible effect. It also highlights the possible differences if you take it while sedated on one occasion and not the next.
Possibly starting with just an opioid? Would butorphanol be enough? I know it is not in some cases!
Scott 🙂
-
AuthorPosts



