scott@vtx-cpd.com
Forum Replies Created
-
AuthorPosts
-
So helpful!
Thank you for sharing these brilliant videos!
Scott š
Replying to Robyn P. 23/07/2025 - 10:57
Great question!
Lovely o hear from you. I hope you are well and enjoying the course.
For Diff-Quik or similar Romanowsky-type stains, hereās whatās generally recommended to maintain stain quality and avoid cross-contamination:
Recommended Frequency of Changing Stain Solutions:
Every 100ā150 slides is a common general rule of thumb.
More frequently if youāre processing dirty or infectious samples, like abscesses, ear swabs, or cytologies from ulcerated masses. These contaminate the fixative and stain solutions much more quickly.
If you notice stain precipitate, contamination, or colour shift, thatās a red flag the stains need changing ā even if you havenāt hit the āslide limit.ā
At least monthly is a good minimum for routine use in low-throughput clinics, even if the stain still looks OK.
Best Practice:
Use separate stain sets for potentially contaminated samples (like ear or faecal swabs) versus clean cytologies (like lymph nodes or FNA of internal organs).
Always close the lids tightly and avoid topping up old solutions ā replace fully.
Clean and dry the Coplin jars before refilling.
Document your stain change dates somewhere visible in the lab to help everyone stay on the same page.
I hope that helps! Have a lovely weekend.
Scott š
Replying to Samantha T. 26/07/2025 - 21:59
Thank you Sam!
Really interesting point about the young frustrated cats! That is really valuable to remember.
Scott š
Replying to Josep B. 26/07/2025 - 02:38
Thanks Josep.
This is really interesting. Thank you for sharing your thoughts.
Scott š
Hi Mark,
Thank you for your question. I hope you are enjoying the course. Yes, Iāve been using gabapentin in a similar fashion and agree it can be a game changer for stressed or hospitalized cats when you want to avoid IM sedation. Your examples align closely with mine, Iāve used it in cats with urethral obstruction, pancreatitis, CHF, and even just for routine blood draws in particularly reactive patients. At doses around 50 to 100mg, Iāve found it particularly helpful for reducing the need for chemical restraint, improving compliance for catheter placement or imaging, and making hospitalisation a little easier on everyone.
In terms of evidence, the randomized controlled trial by van Haaften et al. (JAVMA 2017; 251[10]:1175ā1181) is a useful reference. It showed that a single 100mg oral dose given 90 minutes before transport significantly reduced stress scores during transport and veterinary examination in pet cats with a history of stress or fractious behaviour. Veterinarian-assessed compliance scores also improved, and while sedation, ataxia, and hypersalivation were reported, all adverse effects resolved within eight hours. This provides solid backing for its use pre-visit and supports what many of us have observed anecdotally in practice.
Regarding renal disease, the 2022 study by Quimby et al. (J Feline Med Surg; 24[12]:1260ā1266) found that cats with stage 2 or 3 CKD had significantly higher serum concentrations of gabapentin after a single dose compared to healthy controls, even when the CKD group received half the dose. Serum concentrations were correlated with creatinine and SDMA, and compliance scores improved with increasing serum levels. Based on this, Iād be comfortable using gabapentin for a single dose in CKD cats but would definitely reduce the dose, especially if repeating, and avoid chronic use without close monitoring.
Thereās also the 2021 study by Allen et al. (J Am Anim Hosp Assoc; 57[6]:278ā284) showing that gabapentin caused mild sedation in healthy cats and modest but statistically significant reductions in echocardiographic parameters of systolic function, though all remained within normal limits. Thatās reassuring for its use in mild cardiac patients where gentle sedation is needed ā Iāve found it particularly helpful in cats undergoing echocardiography who otherwise canāt be handled.
I agree with your caution about avoiding it in dyspnoeic patients due to the risk of aspiration. For these cats, Iād either delay gabapentin until theyāre stable or use an injectable route if anxiolysis is absolutely necessary.
I will look forward to seeing what the others think!
Have a lovely weekend.
Scott š
Hi Jo,
Thanks for sharing this case. This is a tricky one!
1. Could untreated paroxysmal dyskinesia (PD) cause the PU/PD or the high sodium?
Paroxysmal dyskinesia itself doesnāt have a known causal link to hypernatremia or PU/PD. It is a movement disorder without established systemic or metabolic sequelae. However, if the episodes are prolonged or more frequent than recognised, one theoretical possibility is that excessive panting during or after episodes could contribute to insensible water loss, although this would typically lead to free water depletion rather than sodium gain ā and would not explain persistent isosthenuria or the absence of compensatory polydipsia unless there’s impaired thirst (see below).
So, while PD is very unlikely to be the primary driver, itās still important to ensure the dyskinesia isnāt masking other neurologic signs that could indicate central causes of thirst or ADH dysregulation.
2. Could this be primary diabetes insipidus (DI)?
Yes, central DI (CDI) remains a plausible differential, particularly given:
Hypernatremia (Na = 170)
Isosthenuria (USG 1.010)
A clinically well dog with minimal systemic signs
That said, Iād add that in patients with psychogenic polydipsia or diabetes insipidus, the PU/PD that owners observe is often quite dramatic, so I would be a bit surprised if this had gone unnoticed, even in a multi-dog household. If they havenāt seen obvious polyuria or polydipsia, Iād lean more toward intermittent leakage or a true storage disorder as the more likely cause of the nocturnal incontinence.
That being said, I do think itās worth ruling out other causes of PU/PD as comprehensively as possible before committing to a diagnosis of urethral sphincter mechanism incompetence (USMI) alone. Specifically:
Check ionized calcium
Perform an abdominal ultrasound (both for kidneys and adrenals)
Review diet and treats (for salt intake)
Consider a desmopressin trial over a water deprivation test, I agree that a WDT wouldnāt be indicated here given the current hypernatremia
If thereās any suggestion of CDI or hypodipsia, a trial of DDAVP (desmopressin) is low-risk and diagnostically useful: if the dog concentrates his urine and sodium normalises, that would support central DI. And if thereās leakage at night that persists independently of water balance, then USMI is very likely ā and it may have been tipped over the edge by mild underlying polyuria or decreased urethral tone with age.
I’ll double check with our neurologist as well, but Iād say based on the information so far, this sounds more like a storage disorder, and Iād be inclined to continue treatment for incontinence while also covering your bases diagnostically.
3. Could propalin (phenylpropanolamine) affect the paroxysmal dyskinesia?
Thereās no strong evidence of an association, but theoretically, as a sympathomimetic, PPA could lower seizure threshold or increase CNS excitability. While PD is not epileptic in nature, there may still be overlap in some patients with idiopathic movement disorders.
If you notice an increase in frequency, duration, or severity of dyskinesia episodes after starting propalin, it would be worth reconsidering. On the other hand, if the incontinence is actually secondary to polyuria, addressing the underlying cause (e.g. DI or CKD) will be more effective than treating the sphincter alone.
Hypernatremia almost always reflects a relative or absolute water deficit, and far less commonly, excess sodium gain. The causes can be grouped as follows:
Pure water loss (e.g. diabetes insipidus, panting, inadequate intake)
Loss of hypotonic fluids (vomiting, diarrhoea, CKD, AKI, diuretics)
Salt intoxication (e.g. homemade playdough ingestion)
Hypodipsia or adipsia (congenital or acquired hypothalamic dysfunction)
Iatrogenic sodium gain (e.g. hypertonic saline, NaHCOā, high-Na diet)
Endocrine causes (hyperaldosteronism, hypercortisolism ā rare to cause frank hypernatremia but do promote sodium retention)
Next steps might include:
Recheck serum sodium and osmolality to confirm degree and trend
Ionised calcium (to exclude hypercalcaemia-driven PU/PD)
Abdominal ultrasound for kidneys, adrenals, and bladder
Desmopressin trial (diagnostic and potentially therapeutic)
Continue PPA trial, with caution and monitoring of PD episodes
Consider MRI or neurologic consult if concern for central hypodipsia emerges
Let me know what you find. Really appreciate you sharing this one!
Have a great weekend.
Scott š
Replying to Felipe M. 25/07/2025 - 12:14
Wise words as always Felipe!
Thank you for sharing your thoughts.
Have a great weekend.
Scott š
Replying to Jo T. 24/07/2025 - 08:27
Thanks Jo.
So glad it was helpful! Let us know if you have any other questions.
Scott š
Replying to Christina Frigast 24/07/2025 - 09:02
Hi Christina,
Thanks so much for the reply!
Really interesting to hear that youāve started reaching for corticosteroids a bit earlier in select cases. Iāve had a similar experience where, in dogs with persistent SIRS or cases that arenāt turning the corner despite appropriate supportive care, a cautious steroid trial has made a noticeable difference. I think as the evidence base continues to grow, weāll all get more comfortable identifying when and where they can be most beneficial.
Totally agree with you on the gastroprotectants too. Omeprazole seems to be part of the default āpancreatitis protocolā in many clinics, regardless of GI bleeding or ulceration risk. I think itās a reflection of good intentionsābut as you said, if there’s no vomiting blood, melena, or stress-related concerns, we may be overusing it in some cases. That said, I still reach for it quickly if thereās any question of GI mucosal compromise or concurrent NSAID use.
Really appreciate the chance to chat through this!
All the best,
Scott š
Hey Christina!
Thank you for sharing such an interesting case. Definitely one for Liz! I will make sure she sees it.
This sort of case would stress me out!
Scott š
Replying to Rosie Webster 24/07/2025 - 22:47
Hey Rosie.
Great to see you here. I totally agree. I rarely reach for anything else.
Fluids seem to sort out a lot of problems!
I hope you are enjoying the course.
Scott š
Replying to Sarah Keir 24/07/2025 - 11:53
HAHAH!
I love the commitment! Maybe knowing who you dressed us as would help us decide the house?!
Scott š
Replying to Sarah Keir 24/07/2025 - 11:56
Great question!
Currently we only do radiography. Do you think ultrasound cases and images would work in this kind of forum/discussion session?
Certainly happy to try! Would love to hear your thoughts.
Scott š
Replying to Felipe M. 19/07/2025 - 15:37
Felipe,
Thank you so much for the reply.
Scott š
Hey!
The reply from Felipe:
“Hi Jo
Itās fantastic to hear you are enjoying your experience. Hospital settings can be lots of fun.
Great question, and one that does not have a straightforward answer.
The reality is we do not have much evidence in terms of the effects of SQ or IM single doses of ketamine for pain relief. SQ pulse ketamine therapy is a fairly popular choice, where the patient gets an injection of around 0.5mg/kg SQ every so often (it can be days, weeks or even months) as part of a chronic pain plan. It would be wishful to think the ketamine hangs around for such a long time to help our patients, as realistically it will be gone in no more than a couple of hours. What we hypothesise is that the transient effect in down-regulating the wind-up part of chronic pain (through NMDA receptor antagonism) helps get control of pain, yielding relief for some time (until the wind-up gets set in again). I do use it regularly and find it works, as so do many colleagues. However there are no studies on this. It would be very difficult to replicate in an uniform and reliable way to get trustworthy results. When we are in need of proper control of chronic pain though, a ketamine infusion for some hours, or even days, is definitely the way to go. Hope you find this useful!
Interestingly, there is a paper which documents the absorption and pharmacokinetics of SQ ketamine (albeit delivered constantly through an insulin pump) in dogs (DOI https://doi.org/10.1111/jvp.13440) and another one in the positive effects of SQ ketamine given on postoperative pain in humans (DOI https://doi.org/10.1007/s12630-017-0914-0).
Great topic
Felipe”
-
AuthorPosts