scott@vtx-cpd.com
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Sara…
Were they saying that the alpha 2’s had a renoprotective effect? Could you ask them a bit more about it/do they have a reference. Not something I have heard before and really interesting!
Thanks for that.
Scott 🙂
Really interesting!!!
Is this generally, or in cases of urethral obstruction. I have not heard this but have just fired off an email to an anaesthesia specialist to find out more! I will let you know.
Scott 🙂
Keppra is a good shout!
I often escalate like Zoe says. Diazepam/midazolam first choice with phenobarbitone next and then Keppra, then propofol?! It often feels like we are giving all at once!
Scott 🙂
Hey.
It does seem like it was a last resort in these cases. What would you use in really refractory cases in practice?
Scott 🙂
Thanks.
Is the diazepam and methadone alone enough to unblock some?
Scott 🙂
Indeed… spread the word!
It is a nice paper.
Scott 🙂
It seems cost is the biggest issue.
That is such a shame because it is so much easier! I still have nightmares about having to give them that powdered form!
I wonder why is costs so much?! I would heave thought the active ingredient was quite cheap!
Scott 🙂
Great question Sara and great points Simon.
There are a couple of studies in dogs where both drugs are used. Problem is that most involve maropitant being given and then around an hour later the apomorphine is given:
https://pubmed.ncbi.nlm.nih.gov/28042152/
https://pubmed.ncbi.nlm.nih.gov/19000276/I think the main point is due to the timing of the drug administration and how long to peak effect. If we are giving the maropitant SC after the apomorphine, it is probably starting to work after the emetic effect of the apomorphine has passed. I think it probably has little effect.
Makes us feel better for sure.
Scott 🙂
I think that is a really good point.
I definitely use them in a cumulative way. If maropitant id not effective enough. I will add in metoclopramide and then ondansetron. I really do think some cases need all three.
Scott 🙂
Interesting!
Have you often given it IV?
Scott 🙂
Really interesting!
It is really nice that you have a few units in stock. We probably do not see enough cases to justify having it is stock. The Portuguese Blood Bank is amazing. If we order the feline blood before 4pm one day we have it the next!
What about in an emergency situation when there was not time for the external crossmatch. Based on this paper would you consider using one of the appropriately typed units even if they do not crossmatch?
Scott 🙂
Was there a peritonitis associated. I presume the penetrating woud was small so not significant leakage?
Scott x
The cost does seem to be the issue… It is so much easier though.
Scott x
It is amazing how these sharp objects can migrate through the GI tract wall. I have seen one penetrate the spleen too before.
The dog had surgery and actually did really well.
Scott 🙂
I think it is about choosing the right cases. I definitely think they have a place in cases where animals have a diagnosis and are already being appropriately treated. I can understand his concerns as there will be cases where it just becomes a way of making them eat.
The drug I was talking about above is definitely worth looking in to:
Scott 🙂
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