Replying to Sarah Keir 25/08/2025 - 15:27
Hey Sarah!
Thanks so much for your reply.
Following the most recent biopsy, I’ve opted for a preventative strategy focused on stabilising ALT and mitigating long-term hepatic damage. In terms of management, I’ve added:
Zinc supplementation at 8–10 mg/kg/day of elemental zinc, divided BID, to limit further copper uptake and enhance hepatic sequestration. We’ll monitor serum zinc to guide dosing and avoid toxicity.
Vitamin E at 10 IU/kg/day (capped at 400 IU), aiming to provide antioxidant and anti-fibrotic support.
Liver-specific diet: transitioning to Purina Liver Support (HP), primarily for its reduced copper content. I appreciated your point about protein levels, I’ve flagged this to the owners to monitor condition score and muscle mass. Fortunately, Anchor is in excellent condition and the food is well tolerated so far.
Continuing supportive therapies: Denamarin, ursodiol, vitamin B12 injections, taurine, and probiotics.
We’re planning to recheck ALT, AST, ALP, GGT, B12, and serum zinc 12 weeks after all changes are in place.
The owners were understandably a bit hesitant about corticosteroids for now, especially given how well Anchor looks clinically. That said, I’ve left the door open to revisit a steroid trial if ALT remains persistently elevated or if clinical signs evolve.
Hope all is well with you otherwise!
Scott 🙂
