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scott@vtx-cpd.com

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  • scott@vtx-cpd.com
    Keymaster
    13:53 05/02/20

    Hey.

    I think we would consider the average lifespan of the cells to be around 4 days. So not long, but will be lifesaving in the moment!

    Scott x

    scott@vtx-cpd.com
    Keymaster
    13:52 05/02/20

    Good point!

    They are an amazing resource! We did actually order blood from them. We got this next day delivery but the cat had an acute deterioration. I think this is a great example of how immediately life saving the xenotransfusion can be!

    I love getting the delivery of cat blood from Portugal! The little bags of blood are so cute!

    Scott 🙂

    scott@vtx-cpd.com
    Keymaster
    13:51 05/02/20

    Good point!

    They are an amazing resource! We did actually order blood from them. We got this next day delivery but the cat had an acute deterioration. I think this is a great example of how immediately life saving the xenotransfusion can be!

    I love getting the delivery of cat blood from Portugal! The little bags of blood are so cute!

    Scott 🙂

    scott@vtx-cpd.com
    Keymaster
    13:49 05/02/20

    It is definitely not as high risk as we maybe thought.

    There is no specific recommendation for any measures above and beyond what we would do for a ‘normal’ transfusion. Careful monitoring and slow rate to begin with.

    Scott 🙂

    scott@vtx-cpd.com
    Keymaster
    13:47 05/02/20

    How long after the xenotransfusion did you give the feline transfusion?

    Scott 🙂

    scott@vtx-cpd.com
    Keymaster
    13:46 05/02/20

    Thank you for the question.

    I have no direct experience using it but have had a look at the information available. Cartrophen Vet is not approved for use in cats but vets are using it off-label (cascade system) in cats for the treatment of arthritis following owner consent. There seems to be very limited research overall:

    https://www.ncbi.nlm.nih.gov/pubmed/2481039
    https://www.ncbi.nlm.nih.gov/pubmed/12779171

    I could only find the two publications above looking directly at the veterinary literature. The following paper is the only one listed on the Cartrophen website:

    http://www.cartrophen.com/wp-content/uploads/2016/07/Pentosan-polysulfate-as-a-disease-modifier-of-cartilage-degeneration-inexperimental-osteoarthritis_Journal-of-Arthrtitis.pdf

    What is your experience?

    Scott 🙂

    scott@vtx-cpd.com
    Keymaster
    13:38 05/02/20

    This is so interesting.

    I have looked at this again and spoken to neurology and surgical collegues. I do not think there is good literature to support a bladder size guide in dogs. We will assess patients on a very individual basis. I also think it is interesting to consider the method of supporting urination. Indwelling atheter vs expression vs intermittent catheterisation. I have popped an interesting papaer below.

    I also saw a paraplegic dog this week with a sacral implant so that the owner could control exactly when the dog voided urine! How cool. I have posted a paper below.

    https://www.ncbi.nlm.nih.gov/pubmed/19121176
    https://www.ncbi.nlm.nih.gov/pubmed/23194073

    Thank you again for starting this great discussion!

    Scott 🙂

    scott@vtx-cpd.com
    Keymaster
    21:59 10/01/20

    https://www.ncbi.nlm.nih.gov/pubmed/?term=rapid+vascular+uptake+of+contrast+cat

    scott@vtx-cpd.com
    Keymaster
    21:57 10/01/20

    My heart was in my mouth! It reminded me of the contrast studies we were trying to achieve when we were doing the intrahepatic shunt. You do it better when you are not even trying! x

    scott@vtx-cpd.com
    Keymaster
    21:56 10/01/20

    Air embolism is definitely reported as a potential risk of doing contrast studies. When I worked at the Vet School we used CO2 and not air for this reason. The complication that we saw here was a whole other level. There is only one other case report in a cat showing this. I don’t think this should stop us doing these studies… but it definitely made me STOP… and think!… and panic a bit! x

    scott@vtx-cpd.com
    Keymaster
    11:23 26/11/19

    The contrast has leaked in to the vena cava! I cam up to a point of resistance with the urinary catheter at the level of the prostate. Injected contrast under a normal amount of pressure. I presume that the disease within the prostate was so severe that it allowed contrast leakage through the tissue. It just blows my mind that the path of least resistance was the vena cava!!! Scott 🙂

    scott@vtx-cpd.com
    Keymaster
    11:20 26/11/19

    This is a slightly more normal urethral study. In this image you can see some contrast entering the bladder:

    Normal-Urethral-Study

    Scott 🙂

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