scott@vtx-cpd.com
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Replying to Rachel D. 06/10/2021 - 15:01
Thank you!
Really pleased it is helping!
Scott 🙂
Replying to Rachel P. 06/10/2021 - 12:40
Hey Rachel.
Thank you so much! I really wanted to follow through with my promise to make it easier to understand!
Scott 🙂
Replying to Nicola F. 04/10/2021 - 14:52
Hello.
Some suggestions from Hilary!
”Thank you for your question; pruritus in cats can be challenging
Regarding flea treatment – have you treated all animals and the house?
If you can rule out parasites then a food trial would be indicated _ I recommend a hydrolysed diet for 6 weeks. Regarding the prednisolone treat 2mg/kg daily until the pruritus is controlled and then taper, if starting a diet trial then I wouldn’t taper until 4 weeks into the diet trial. If they don’t want to do this then consider ciclosporin but this needs 4 weeks to full effect therefore run the prednisolone along with it for 2-3 weeks”Hope that helps.
Scott 🙂
Hey.
This article has just been released in JVIM, thought it was good timing for your case!
Clinical features and amino acid profiles of dogs with hepatocutaneous syndrome or hepatocutaneous-associated hepatopathy
Abstract
Background: Superficial necrolytic dermatitis (SND), hepatocutaneous-associated hepatopathy (HCH), aminoaciduria, and hypoaminoacidemia define hepatocutaneous syndrome (HCS) in dogs. Dogs without SND but that possess all other syndrome components are not well described.Hypothesis/objectives: To define an inclusive syndrome, aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) for dogs with HCH or HCS. Compare clinical features, salient clinicopathologic variables, and plasma and urine amino acid (AA) profiles among ACHES cases by skin lesion status.
Animals: Dogs of various breeds and ages diagnosed with ACHES (n = 41). A control (CON) cohort (n = 12) provided AA profile data.
Methods: Retrospective case series. Available medical records of previously identified cases were reviewed for salient clinical features and clinical pathology data. Plasma and urine AA profiles were performed. Cutaneous lesion status was classified as none, mild, or fulminant.
Results: Thirty cases (73%) developed SND at some time. Dogs with fulminant skin lesions at diagnosis (n = 22/41, 54%) had significantly lower hematocrit (P = .05) and mean corpuscular volume (P = .01) than dogs without SND. Principal component analysis of plasma AA profiles identified distinct clustering of CON from ACHES dogs, but not by skin lesion status. Plasma 1-methylhistidine (<7 nmol/mL) and cystathionine (<7.5 nmol/mL) were robust ACHES biomarkers. Urine lysine (>344 nmol/mg creatinine) and methionine (>68 nmol/mg creatinine) also were useful ACHES biomarkers.
Conclusions and clinical importance: Specific AA biomarkers provide additional diagnostic utility in ACHES. Data suggests that HCH is an early stage, and SND a later stage manifestation of ACHES.
Scott x
Replying to Nicola F. 04/10/2021 - 14:52
Hello.
I hope you are well. Thank you for your question. I will pass this on to Hilary and let you know.
Scott 🙂
Replying to Hannah Sivills 04/10/2021 - 20:16
Lovely to hear from everyone.
Thank you for the feedback regarding the first session. Would be great to have your feedback. Acid base can be a tough sell!
Scott 🙂
Replying to Rosemary S. 05/10/2021 - 11:29
Really lovely to hear from you.
Really interesting that you have done an oncology internship… I may have some questions for you! Oncology is not my strongest point!
Hope you enjoy the course.
Scott 🙂
Replying to Michelle S 05/10/2021 - 11:38
No problem!
Glad you liked it.
It is also a good reminder to anyone who has not send me their address yet!
Thanks again.
Scott 🙂
Replying to Liz Bode 04/10/2021 - 20:50
Hey.
We use it in cats too. They don’t love the taste of it and can salivate a bit. It works well in cats too, I I would definitely recommend. I still use a lot of mirtazapine in cats too.
Scott 🙂
Replying to Jacquin M. 03/10/2021 - 17:25
Hey.
I think my main tip with the multiparameter monitor is to get it out the cupboard and dust it off. I used to work in a practice where we only used it in unstable cases.
I would get in to the habit of using it in all cases. It all then becomes second nature. You learn from the stable cases, and know when things go wrong with the unstable cases!
Scott 🙂
Replying to Lesley M. 03/10/2021 - 12:00
Hey.
I honestly use gabapentin in this case. There is also then the option to give further doses. I think would also be better from a ‘safely’point of view.
I wish I had a similar protocol for when I take my children on a plane!
Scott 🙂
Hello everyone!
Just wanted to say hello too. My name is Scott and I have the privilege of taking you through the first lesson.
Please let me know if you have any questions at any time. If you are not comfortable popping them on the discussion forum then drop me an email:
I look forward to hearing a bit about you all.
Scott 🙂
Replying to Elizabeth D. 28/09/2021 - 22:06
Hey Elizabeth.
Really interesting question. It is not currently recommended to giev omeprazole in cases that are being given high doses of steroids.
No evidence from clinical reports of dogs or from research studies shows that gastroprotectant drugs are beneficial for preventing or decreasing GI complications from high doses of corticosteroids. The gastroprotectants used in these reports were sucralfate, misoprostol, and H2RAs (ranitidine, famotidine). Some of these reports were from the 1980s, before the use of PPIs, although a more recent study showed no benefit in healing or preventing development of gastric mucosal lesions in dogs using either misoprostol or omeprazole.
I hope that helps.
Have a lovely weekend.
Scott 🙂
Replying to Elaine P. 30/09/2021 - 19:42
Hello.
Hope you are well and enjoying the course!
Trazodone can be administered as needed, daily as often as every eight hours, or by using a combination of the two schedules. Because of the wide range in reaching peak plasma concentration and in its half-life, it is important to recognize that dosing should be adjusted to account for this individual variability. Trazodone is dosed at 1.7 to 9.5 mg/kg orally every eight to 24 hours. It is recommended to begin dosing at 2 to 3 mg/kg orally every 24 hours and then gradually taper up to effect.
I would recommend giving the trazadone and gabapentin around 2 hours before the visit to the vets.
Scott 🙂
Replying to Ilse v. 28/09/2021 - 01:48
Hello Ilse,
Hope you are well. Thank you so much for your question. There definitely is a suggestion that using peripheral blood (ear tip) may be better for the detection of Babesia.
I would not use a peripheral sample for anything else. Taking from a small vessel may be detrimental when assessing other parameters (particularly platelets).
An atraumatic sample from a bigger vessel is best for everything else.
Hope that helps.
Scott 🙂
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