Reply To: Spleen Cytology!

Replying to Sarah Clements 02/12/2021 - 20:53

HAHAH!

Fair enough! I have popped the path report below! Hope that helps:

Site Spleen

Microscopic Description

Ten scanned sections from three aspirated smears are examined. The cellularity is variable, with areas
containing numerous neoplastic cells. The preservation is good. The background contains and large
amount of blood. The neoplastic cells have often exfoliated in aggregates, occasionally associated with small capillaries. Lower numbers of cells are individualized. They are mononucleated with occasional multinucleated forms.
They are plump oval to spindleoid and display moderate anisokaryosis and anisocytosis. They have large, round to oval nuclei with granular chromatin and often multiple small and variably visible nucleoli. The nucleoli occasionally vary in size within the same nucleus. The cytoplasm is moderate in amount and moderately basophilic, with poorly defined margins. It occasionally contains small clear vacuoles and rarely amorphous phagosomes. Scattered around there are also low numbers of mixed haematopoietic precursors and low numbers of mixed lymphoid cells.

Microscopic Interpretation

Malignant neoplasm. Differential diagnoses: sarcoma (e.g. splenic stromal sarcoma) and histiocytic
sarcoma.

Comments

As you suspected, the aspirate from the spleen are consistent with a neoplastic process. The primary
differential diagnoses would include a sarcoma, such as a splenic stromal sarcoma and possibly and a
histiocytic sarcoma. Subjectively, a histiocytic sarcoma appears in this case possibly less likely because,
although the individual cell morphology is compatible with this neoplasm, the arrangement of the cells in
aggregates is quite unusual. Nevertheless, it cannot be excluded. A haemangiosarcoma appears unlikely
morphologically.

Similar cells are not observed in these sections from the liver where no significant cytological abnormalities
are observed, beside the very mild and non specific hepatocellular vacuolation. However, depending on the
imaging findings, these preparations may not be fully representative.