Reply To: Phenobarbital toxicity
How did you get on with this case? Did the haematological abnormalities improve once the Phenobarb was stopped?
I came across my first case of phenobarb induced hepatoxocity a couple of weeks ago, (progressive elevation of ALT/ALP and dropping ALB, and acute onset PU/PD. Liver biopsies had histological changes which were consistent with phenobarb toxicity), so he is currently coming of his phenobarbitone and monitoring to see how his liver parameters respond.
I hope your patient is responding well.