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Reply To: Trauma by Elephant!

Homepage Forums Clinical Discussions Trauma by Elephant! Reply To: Trauma by Elephant!

#58802

Hey Inga.

I thing the possibilities are endless with this drug!

“Tranexamic acid (TXA) is an antifibrinolytic agent that exerts its effects by reversibly binding to the lysine sites on plasminogen molecules and inhibiting plasmin. TXA is widely used in human medicine and decreases mortality, reduces blood loss after trauma or surgery, and lowers transfusion requirements in trauma patients with bleeding. TXA has been shown to decrease mortality over placebo in trauma patients, It is also noted to have good safety parameters upon administration and is recommended for use in human trauma patients with bleeding.

In veterinary medicine, TXA has been used to reduce blood loss by slowing fibrinolysis in various diseases causing clinical bleeding such as hemoperitoneum, haemothorax, thrombocytopenia, anticoagulant rodenticide intoxication, peri-operative bleeding, epistaxis, and feline interstitial cystitis-associated bleeding. It has a wide safety margin and is rarely associated with hypersensitivity reactions. In humans, common side effects of TXA are mild symptoms including nausea, flushing, vomiting, allergic skin reactions and headache, although anaphylactic shock is rarely reported. In dogs, the main reported side effect is vomiting”.

I think there is a lot more to come!

Scott 🙂