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Reply To: How does intralipid work?
I think both theories are in their infancy, but there appears to be growing evidence for a role of both these theories. The cardioprotective theory involves the intralipid being able to improve myocardial metabolic function, even reversing some of the effects of ischaemia, which will provide more energy for the heart. It also enhances some calcium handling within the heart which improves inotropy and repairs any lost function present that may have been caused by cardiotoxic drugs. Most evidence appears to be in the use of anaesthetics in people.