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Reply To: Ranitidine

Homepage Forums Clinical Discussions Ranitidine Reply To: Ranitidine

#52541
Simon Patchett
Participant

Hi Gail,

You got me thinking about what evidence there is for ranitidine use in rabbits, it’s something I was taught to give at university and have used it in practice without ever really looking for an evidence base.

So evidence wise, I found this (amongst others)… as you said largely a prokinetic, and a convincing one at that!

https://www.sciencedirect.com/science/article/abs/pii/S1043661800907850?via%3Dihub

In this paper they removed the intestines of rabbits duodenum to rectum and then assessed its contractility in an organ bath following administration of ranitidine. Ranitidine demonstrates a concentration dependent contractile effect on the duodenum, ileum and ascending colon. They also looked at whether cisapride potentiated the effect (main aim of the paper) and concluded that up to a certain threshold it did but thereafter it actually antagonised the effects of ranitidine. There aren’t any doses in the paper but I think it nicely demonstrates the effects of the medication.

Hope that it is of interest..!
Simon 🙂