Diabetic ketoacidosis (DKA) is a serious and potentially life-threatening complications of diabetes mellitus (DM). Patients with DKA are often very ill, their management challenging, and concurrent conditions that can substantially affect prognosis are common. Fluid, electrolyte and acid-base disturbances can be significant. In this webinar we review pathophysiology and clinical signs. We discuss tips and tricks to get the most out of in house diagnostics. The big question is… which insulin and how to give it!